摘要
目的探讨黑龙江地区丙型病毒性肝炎病毒基因型与亚型的分布特点及临床意义,为临床制订合理的治疗方案和判断预后提供参考依据。方法在116例抗丙型肝炎病毒(HCV)抗体和HCV RNA均为阳性的血清标本中,提取HCV RNA并进行基因分型检测。同时收集患者的基本资料、感染途径、肝功能检查结果等进行登记分析。结果黑龙江地区丙型病毒性肝炎病毒基因型以1b型为主,占50.0%,其次为2a型。不同感染途径HCV患者间基因分型构成无显著性差异,不同疾病程度患者的HCV基因型分布差异有显著性,1b型丙型病毒性肝炎患者HCV RNA含量及脂肪变性发生率均高于2a型,差异均有显著性(P均<0.05)。结论黑龙江地区流行的HCV基因型主要为1b型,并呈现一定的多样性,且HCV基因型与疾病严重程度有一定的相关性,基因型分型的检测对病情的进展及预后有一定的预测作用。
Objective To explore the distribution and clinical signiifcance of genotypes and subtypes of hepatitis C virus （HCV） in Heilongjiang province and provide basis for the clinical treatment and prognosis. Method HCV RNA was extracted and genotypes and subtypes was tested in serum samples that anti HCV antibody and HCV RNA were all positive. The basic information, route of infection, the result of liver function of patients was collected at the same time. Result The main hepatitis C virus （HCV） genotype in Hei-longjiang province was 1b type, accounted for 50.0%, and followed by 2a type. The genotyping constitute between different route of infection was no signiifcant difference. The genotyping constitute between different degree of disease was statistically significant. The content of HCV RNA and fatty degeneration rate of 1b type in patients with hepatitis C were higher than 2a type （Pall〈0.05）. Conclusion The HCV genotype of Heilongjiang province was 1b type and had diversity, the HCV genotypes and liver disease severity has certain relevance. The detection of genotype classiifcation has prediction effect for the progress and prognosis.
出处
《中国医学前沿杂志（电子版）》
2014年第9期30-32,共3页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
黑龙江省卫生厅课题(2009-144)
哈医大二院青年启动基金(QN2009-07)
关键词
丙型病毒性肝炎
肝炎病毒
基因型
亚型
黑龙江
Viral hepatitis type C
Hepatitis C virus
Genotypes
Subtypes
Heilongjiang province
