摘要
目的探讨化湿行瘀清热方剂对口腔扁平苔藓(OLP)的治疗作用。方法选择30例OLP患者和30例正常人,通过全自动生化分析仪进行唾液中谷丙转氨酶(ALT)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)含量的检测,并对OLP患者采用化湿行瘀清热方剂治疗,观察治疗6周后的临床效果以及治疗前后唾液中ALT、AST、LDH含量的变化。结果 OLP患者组经化湿行瘀清热方剂治疗6周后,自觉症状消失或有不同程度的减轻,充血、糜烂、白色病损消失或减轻;OLP患者组治疗前唾液中LDH含量明显高于正常对照组,ALT、AST含量与正常对照组无明显差异,经用化湿行瘀清热方剂治疗6周后唾液中LDH含量明显降低。结论化湿行瘀清热方剂在治疗口腔扁平苔藓上有明显的临床效果;唾液中ALT、AST水平与OLP无明显关系,LDH含量的升高可能与OLP的发生有关。
Objective To investigate the therapeutic effect of Huashi Xingyu Qingre decoction on oral lichen planus. Methods 30 cases of OLP patients and 30 normal people were selected and the content of ALT,AST,LDH in saliva was detected by automatic bio- chemical analyzer,the OLP patients were treated by Huashi Xingyu Qingre decoction,and the clinical effect 6 weeks after treatment and the changes of ALT,AST,LDH in saliva before and after treatment were observed. Results In the group of patients with OLP by Hua- shi Xingyu Qingre decoction 6 weeks after treatment, symptoms disappeared or reduced to different degrees, and hyperemia, erosion, white lesions disappeared or reduced; in the group of patients with OLP,its LDH content in saliva was significantly higher than that of the normal control group. There was no obvious difference between OLP group and the control group in ALT, AST content,but the con- tent of LDH by Huashi Xingyu Qingre decoction reduced obviously in the saliva 6 weeks after treatment. Conclusions Huashi Xingyu Qingre decoction has obvious clinical effect on oral lichen planus; Salivary ALT,AST levels had no significant relationship with OLP, and the increased LDH levels may be associated with the occurrence of OLP.
出处
《口腔医学》
CAS
2014年第10期730-733,共4页
Stomatology
基金
国家自然科学基金资助项目(81273813)
河北省科技厅项目(12276104D-41)
河北省中医药管理局项目(2011013)
河北省卫生厅项目(20100125)
