摘要
本文通过对43例口腔扁平苔藓(OLP)患者混合全唾液 pH 值、流率、乳酸脱氢酶(LDH)及其同工酶谱的测定分析,发现 OLP 的发病与其外环境——唾液的变化有十分密切的关系。LDH及其同工酶是组织破坏的敏感指标,本研究结果显示,OLP 患者唾液 LDH 总活性高于对照组(P<0.05),其中糜烂型较非糜烂型高。患者唾液同工酶中,LDH_1、LDH_2、LDH_3降低,LDH_4、LDH_5升高(P<0.01),说明 LDH 的变化与 OLP 病情的轻重有关,是一有用的辅助判断病情及预后的客观生化指标。
It is found that oral lichen planus(OLP)is closely related to its environment-salivarychanges through the analysis of lactic dehydrogenase(LDH),isoenzyme spectrum,pH valueand flow rate in mixed whole saliva collected from 43 cases of the pateints with OLP.LDHand isoenzyme are proved to be sensitive indices of tissue damage.The present study showsthat the total activity of LDH in saliva of the patients with OLP is higher than that ofthe control group(P<0.05),and the erosive type,moreover,is also higher compared withthe nonerosive.The decreases of LDH1,LDH2,LDH3 in isoenzyme of the patients andmeanwhile the increases of LDH4 and LDH5(P<0.01)indicate LDH's changes are ofimportance to the state of OLP,and therefore LDH is useful to help the diagnosis of thedisease,and acts as objective biochemical indices of prognosis.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
1989年第3期146-150,共5页
West China Journal of Stomatology
基金
国家教委基金课题
