摘要
锌α2糖蛋白(ZAG)是2004年被确认的脂肪细胞分泌的一种新型脂质动员因子,它能强烈地促进脂肪分解,明显降低人和小鼠的体重。ZAG促进脂肪分解的作用是通过激活细胞膜上的β3肾上腺素受体和细胞内的cAMP信号转导途径完成的。ZAG在促进脂肪分解的同时还促进脂肪利用,增加产热和脂肪酸β氧化。ZAG能促进脂联素、抑制瘦素在脂肪细胞和脂肪组织中的表达。同时脂肪细胞中ZAG的表达也受地塞米松、脂多糖、肿瘤坏死因子-α、肾上腺素受体激动剂等多种因素的调节。ZAG基因序列分析的研究结果提示,ZAG可能是调节体重的一个候选基因。
Zn-α2-glycoprotein（ZAG） is first identified as a new lipid-mobilizing factor （LMF） secreted by adipocytes in 2004. Treatment with ZAG significantly stimulates lipolysis in isolated mouse and human adipocytes, and reduces body weight in human and mice. The lipolytic effect of ZAG has been attributed to activation of β3 adrenergic receptors and upregualtion of cAMP. ZAG not only has the capacity to induce lipolysis in adipocytes, but it also has the potential to promote lipid catabolism and utilization. ZAG increases adiponectin expression and decreases leptin expression in adipocytes and adipose tissue. Meanwhile, ZAG expression is regulated by dexamethasone, lipopolysaccharide （LPS）, tumour necrosis factor-α and adrenergic receptor agonist. The result of ZAG gene sequence analysis indicated that ZAG is a promising candidate gene for regulation of body weight.
出处
《国际内科学杂志》
CAS
2007年第5期297-300,共4页
International Journal of Internal Medicine
基金
国家自然主任基金(项目编号:30540036)
