摘要
目的:研究醒脑益智胶囊对乙醇致小鼠记忆再现障碍模型的影响。方法:60只昆明种小鼠随机分为空白对照组,模型组,阳性对照组(石杉碱甲),醒脑益智胶囊高、中、低剂量组,每组10只。灌胃40%乙醇复制小鼠记忆再现障碍模型,跳台试验和避暗试验测定学习记忆能力,同时测定脑组织中超氧化物岐化酶(SOD)活力和丙二醛(MDA)的含量。结果:与模型组比较,醒脑益智胶囊高剂量组能延长小鼠潜伏期,减少5min内错误次数,提高SOD活力,降低MDA的含量,有显著性差异(P<0.05)。结论:醒脑益智胶囊有促进记忆和改善乙醇致小鼠记忆再现障碍的作用。
Objective：To study the effects of Xingnao Yizhi capsule on ethology and superoxide dismu tase （SOD）, malonaldehyde （MDA） in brain tissue of dysmnesia mice induced by ethanol. Methods ： Sixty Kunming mice were divided into normal control group,model group,Huperzine-A group,Xingnao Yizhi cap- sule of high dose group,middle dose group and low dose group. There were 10 mice in each group. The memory reproduction disorders model was induced by given 40% ethanol through intragastric administration. Learning and memoring ability of various group rats were assessed with step-through test and step-down test. The content of MDA,activity of SOD in brain tissue were detected. Results：Compared with model group, Xingnao Yizhi capsule of high dose gToup prolonged the latency periods of memo~ , significantly reduced the error times within 5 minutes（P〈0.05）,increased the activity of SOD and decreased the content of MDA in brain tissue（P〈0.05）. Conclusion：Xingnao Yizhi capsule has effects on consolidating learning and memoriz- ing ability of dysmnesia mice induced by ethanol.
出处
《山东中医药大学学报》
2014年第5期475-477,共3页
Journal of Shandong University of Traditional Chinese Medicine
基金
国家重大新药创制专项(编号:2011ZX09102-003-06)
关键词
醒脑益智胶囊
记忆再现障碍
行为学
超氧化物岐化酶
丙二醛
小鼠
Xingnao Yizhi capsule
memory reproduction disorders
ethology
superoxide dismutase
malon-aldehyde
mouse
