摘要
目的观察固本健脑液对学习记忆功能障碍的预防效果。方法分别用东莨菪碱、亚硝酸钠和40%乙醇建立小鼠记忆获得、巩固和再现障碍模型,通过跳台法观察固本健脑液对各组记忆障碍模型小鼠学习记忆三个阶段的影响。结果固本健脑液能显著减少小鼠的记忆错误,与模型组比较其差异有统计学意义(P<0.05)。结论固本健脑液对学习记忆障碍有改善作用。
Objective To study the effects of Gubenjiannao Liquor on learning and memory disorder of mice.Methods Memory acquisition impairment,consolidation disorder,representation disorder were induced by Scopolamine hydrobromide,NaNO2 and alcohol with 40% concentration respectively,upon which step down test was applied to investigate the effects of Gubenjiannao Liquor on the cognitive impairment of mice.Results Gubenjiannao Liquor can markedly decrease memory error（P0.05）.Conclusion Gubenjiannao Liquor could improve the abilities of learning and memory in mice models through multiple ways.
出处
《湖北民族学院学报（医学版）》
2010年第4期1-3,共3页
Journal of Hubei Minzu University(Medical Edition)
基金
国家自然科学基金项目(309400091)
关键词
固本健脑液
学习记忆障碍
跳台法
动物模型
Gubenjiannao Liquor
learning and memory disorder
step down test
animal model
