摘要
目的:系统评价玻璃酸治疗糖尿病足及类似溃疡的疗效与安全性。方法:计算机检索中国生物医学文献数据库、中国期刊全文数据库、维普数据库、万方数据库、Cochrane Library、EMBase、PubMed、SCI,纳入玻璃酸治疗糖尿病足及类似溃疡的随机对照试验(RCT)。根据纳入与排除标准筛选后,依照Cochrane Handbook对纳入的研究进行严格的质量评价,并通过Cochrane协作网提供的系统评价软件Rev Man 5.1进行Meta分析。结果:共纳入10项RCT,合计696例患者。Meta分析结果显示,试验组患者伤口缩小面积[MD=33.58,95%CI(30.80,36.35),P<0.000]、痊愈人数[RR=1.80,95%CI(1.22,2.65),P=0.003]、溃疡伤口平均愈合时间[MD=-8.57,95%CI(-10.79,-6.35),P<0.000]与对照组比较,差异均有统计学意义;两组患者总不良反应发生率比较差异无统计学意义[RR=0.96,95%CI(0.60,1.54),P=0.86]。结论:玻璃酸治疗糖尿病足及类似溃疡可加快溃疡的愈合,提高痊愈率,且不增加总不良反应发生率。后续的研究需增加对患者伤口修复的预后结局指标,同时对成本-效果进行分析。
OBJECTIVE ： To evaluate the effectiveness and safety of hyaluronic acid in the treatment of diabetic foot and simi- lar ulcers. METHODS： Retrieved from CBM, CNKI, VIP, Wanfang database, Cochrane library, Embase, PubMed and SCI, RCT about hyaluronic acid in the treatment of diabetic foot and similar ulcers were included. After screening the literatures based on included criteria, the quality of included studies were evaluated according to Cochrane handbook, and Meta-analysis was conducted by using Rev Man 5.1 software by Cochrane handbook. RESULTS： A total of 10 RCT were included involving 696 patients. Results of Meta-analysis showed that the reduction of wound area [MD=33.58, 95% CI （30.80, 36.35）, P〈0.000], the number of cured patients [RR = 1.80,95 % CI （ 1.22,2.65 ）, P= 0.003], the healing time of ulcer [MD = - 8.57,95 % CI （ - 10.79, - 6.35 ）, P〈 0.000] of experimental group and control group had statistical significance. There was no statistical difference in the incidence of ADR between 2 groups [RR=0.96,95%CI（0.60, 1.54）,P=0.86]. CONCLUSIONS： Hyaluronic acid can accelerate the ulcer heal- ing, meanwhile improve the cure rate. It will not increase the total incidence of ADR. Ulcer repair prognosis index and cost-effec- tiveness analysis are required for subsequent study.
出处
《中国药房》
CAS
CSCD
2014年第32期3049-3053,共5页
China Pharmacy
关键词
玻璃酸
糖尿病足
溃疡
系统评价
META分析
疗效
安全性
Hyaluronic acid
Diabetic foot
Ulcer
Systematic review
Meta-analysis
Effectiveness
Safety
