摘要
本实验分析了受异丙基肾上腺素损伤的心肌线粒体琥珀酸脱氢酶和细胞色素 C 氧化酶的活性,辅酶 Q_(10)的含量,以及全血中的 ATP 含量,结果表明,心肌线粒体辅酶 Q_(10)和全血中ATP,ADP 含量及线粒体上清中琥珀酸脱氢酶活性降低,说明损伤心肌组织的能量代谢发生障碍。我们也开展了复方丹参和辅酶 Q_(10)对心肌保护作用的研究,结果发现这两种药物对心肌有明显的保护作用。
This paper reports the determination of activity of succinic dehydrogenase andcytochrome C oxidase and the content of ubiquinone-10 in damaged myocardialtissue and the content of ATP in blood.We found the content of ubiquinone-10in mitochondria and the content of ATP and ADP in blood and the activity ofsuccinic dehydrogenase in supernatant of mitochondria preperation were lowerthan those of the control group.It indicated that the function of metabolism indamaged myocardial tissue reduced.We also found that FUFANGDANSHEN(salviae miltiorrhizae)and ubiquinone-10 had the function to protect myocardium.
出处
《中国地方病学杂志》
CAS
CSCD
1991年第6期331-334,共4页
Chinese Jouranl of Endemiology
基金
国家自然科学基金
关键词
克山病
心肌损伤
琥珀酸脱氢酶
Succinic dehydrogenase
Cytochrome c oxidase
Ubiquinone-10,ATP
FUFANGDANSHEN
