摘要
目的：研究低硒（Ｓｅ）低维生素Ｅ（ＶＥ）饮食大鼠心肌腺苷酸含量和氧化损伤的关系。方法：使用高效液相测定心肌腺苷酸含量和使用生化方法测定心肌ＭＤＡ含量和ＳＯＤ、ＧＳＨ－Ｐｘ活性。结果：与补充Ｓｅ和／或ＶＥ饮食大鼠相比，低Ｓｅ低ＶＥ饮食大鼠心肌ＡＭＰ，ＡＤＰ含量无明显差异，而ＡＴＰ含量明显降低，ＭＤＡ含量增加，ＳＯＤ，ＧＳＨ－Ｐｘ活性降低，表明Ｓｅ和ＶＥ影响ＡＴＰ含量与其抗氧化作用有关。
To study the relation of the change of energetic material and oxidative damage in rats fed on diet with selenium and vitamine E deficiency (Se,VE DG),adenylic acid was measured by HPLC and MDA,SOD and GSH Px were tested by biochemical method in rat myocardium.The results showed that contents of AMP and ADP were not changed significantly and ATP content was obviously lowered in rats fed on diet with selenium vitamine E deficiency as compared with those in rats with Se and/or VE supplementation.MDA content was increased,activities of SOD and GSH Px were decreased in rats fed on Se,VE DG,but different improvements were found in rats fed on diet with Se VE supplementat.
出处
《中国地方病学杂志》
CAS
CSCD
1998年第6期352-354,共3页
Chinese Jouranl of Endemiology
