摘要
采用最大耐受量和致畸胎试验方法 ,对自拟补肾促产中药复方进行了最大耐受量测定和特殊毒性研究。结果表明 :小鼠灌胃最大耐受量为 10 0g/kg ,超过临床用药 10 0倍 ;试验组畸胎率与阴性对照组差异不显著 ,二者明显低于环磷酰胺组 。
By means of safety limit and teratogenicity test, we conducted study of safety limit and special toxicity in Chinese medicinal compound of enriching the kidney and promoting reproduction. The results indicated that safety limit of the Chinese medicinal compound for mice is 100 g/kg by oral administrotion. It is 100 times higher than therapeutic close. Teratogenic rate of the experimental group is not significantly different from the control group. Both are extremely lower than cyclophosphamide group. It indicates that the compound has not toxic and side effect on pregnant mice and its embryos.
出处
《四川畜牧兽医学院学报》
2000年第3期1-5,共5页
Journal of Sichuan Institute of Animal Husbandry and Veterinary Medicine
关键词
补肾促产中药复方
生殖毒性
最大耐受量
致畸胎试验
Enrich the kidney
Promoting reproduction
Chinese medicinal compound
Special toxicity
