摘要
为开发新的饲料添加剂，阐明其限量和安全性，本试验首次对汪清麦饭石做了较系统的毒理学研究．急性毒性试验结果ＬＤ５０＞２０ｇ／ｋｇ，说明汪清麦饭石属实际无毒类物质．微核试验、精子畸形试验和致畸试验结果表明，在小鼠口粮中添加３．０％以下麦饭石时，致突变阴性（Ｐ＞０．５），无胚胎毒性和致畸作用；添加量达５．０％时，可使小鼠精子畸变率增高（Ｐ＜０．０１），外现畸形率达２．０％．以上结论提示我们，在大剂量使用麦饭石时应引起注意．
in order to develop new additive, toxicological study was first carriedout.Toxic experiment showed LD50>20g/kg which suggested Maifainite belongedto limes matter. After micronuclear,sperm anomaly and anomaly experiment, wemay conduded,if we added 3.0% Maifainite in mice daily feed, mutation wouldbecome negative, and there would have no embryo toxicity and anomaly action;if we added 5.0%,mice sperm distorted rate improved,visual anomaly rate wouldreach 2.0%.So we should pay attention to mass-using Maifainite.
关键词
麦饭石
微核
精子畸形
致畸胎
毒理学
Maifainite
Mice, Micronucleus
Sperm anomaly
Anomaly embryo
