摘要
目的 研究氟对大鼠大脑皮层神经细胞的DNA损伤及硒锌联合对其的影响。方法 体内染毒后采用单细胞凝胶电泳技术检测DNA单链断裂。结果 F组、FSeZn组和SeZn组细胞DNA损伤程度均显著大于对照组 ,各自Ridit值分别为 0 36 4 6 ,0 4 5 5 7和 0 5 2 76 ,显著低于对照组的 0 6 5 2 2 (P <0 0 1) ,3个组相互之间的差异也具有显著性意义 (P <0 0 1)。结论 氟或硒锌合用均可造成大脑皮层神经细胞DNA损伤 。
Objective To investigate on DNA damage induced by fluoride in rats' brain cells as well as the joint effects of selenium and zinc against fluoride.Methods Single Cell Gel Electrophoresis was utilized to detect DNA single strand breaks of neural cells after in vivo exposure.Results The damage degree in F group,FSeZn group and SeZn group was much more serious than that in the control group ( P <0.01).The Ridit value 0.364 6,0.455 7,0.527 6 was lower than control group 0 652 2 respectively.There were marked statistic differences between each other among the three exposure groups( P <0.01).Conclusion Either fluoride or selenium and zinc combined could induce DNA damage in brain cells of rats respectively,yet selenium and zinc presented obvious antagonism effects against fluoride jonintly.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2002年第7期774-775,共2页
Chinese Journal of Public Health
基金
"九.五"国家医学科技攻关项目 (No96 - 90 6 - 0 4 - 0 2 )
