摘要
研究脑络通胶囊对缺血性中风的影响。用三氯化铁引起大鼠大脑中动脉血栓（MCAT）,观察脑络通胶囊对行为障碍、脑梗塞范围、脑水肿程度的影响。结果表明脑络通胶囊80、40、20mg/kg组,可使脑梗塞范围分别减少55％、56％、9％,并使脑含水量下降,行为障碍得到改善。通过急性血瘀大鼠模型实验,表明脑络通胶囊可明显降低模型大鼠全血粘度、增加红细胞变形性,并降低红细胞聚集性。分析显示脑络通胶囊对局部脑缺血的作用可能与其改善血液流变学有关。
The effects of Naoluotong Capsules (NC) on behavior disorder, cerebral infarct size and the degree of cerebral edema were observed in the rats with middle cerebral artery thrombosis induced by FeCl3. The results showed that all the three doses of NC, namely 80, 40 and 20 mg/Kg, could reduce cerebral infarct size by 55% , 56% and 9% respectively, and also, could decrease cerebral water content and relieve behavior disorder. The results from the experiment on NC in the rats with acute blood stasis showed that NC could markedly reduce whole blood viscocity, enhance erythrocyte deformability and weaken erythrocyte aggregation. The mechanism of NC against focal cerebral ischemia might be related with their effects for changing certain hemorheological criteria.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2002年第3期27-30,共4页
Journal of Beijing University of Traditional Chinese Medicine
基金
教育部博士点课题(No.9933)
