摘要
目的 :探讨胃粘膜异型增生中医微观辨证分型与细胞核DNA含量及临床随访结果的关系。方法 :应用中医脏腑辨证理论与图象分析的方法对 12 0例胃粘膜异型增生进行内镜下微观辨证分型与细胞核DNA含量及倍体定量分析 ,同时进行临床随访研究。结果 :胃络瘀滞型与胃络灼伤型胃粘膜DNA含量、超 2倍体、超 4倍体细胞百分数及核平均面积、周长、体积均较胃热型与胃寒型明显增高 ,有显著意义 (P <0 .0 5 ～ 0 .0 1) ,DNA含量直方图非整倍体型组中胃络瘀滞型粘膜(2 6 / 47)明显高于整倍体型组 (8/ 37) (P <0 .0 1)。对其中 6 3例进行了 6～ 72个月 (平均 2 4个月 )的随访 ,癌变组中胃络瘀滞型粘膜 (2 3/ 30 )明显高于未癌变组 (9/ 33) ,差异有显著意义 (P <0 .0 1)。结论 :胃络瘀滞型胃粘膜异型增生与癌变关系密切 ,在辨证施治中应给予重视。
Objective To study The relationship between microcosmic dialectic type of gastric dysplasia and analysis on nuclear DNA content and its significance in follow-up study.Method 120 cases of gastric dysplasia were microcosmic divided dialectically into four types under endoscopy according to gut dialectic theory of traditional Chinese medicine.The nuclear DNA content and morphologic indices of its paraffin sections were quantatively determined by image analisis technique. Result The DNA content,percentage of >2cand>4c cells,and the nuclear morphologic indices in the groups of the Type Gastric Net Resort (TGNR) and Gastric Net Burn(TGNB)were higher than that of the groups of Type Gastric Hot(TGH) and Type gastric cold(TGC)( P <0.05～0.01).the cases of TGNR in DNA aneuploid pattern group (26/47)were higher than that in euploid (8/73)( P <0.01).Sixty-three cases were followed up for 6 to 72 month.There were 23 cases of TGNR in the 30 cases of cancer formation group,but nine in 33 cases of no cancer formation group ( P <0.01).Conclusin The gastric dysplasia with TGNR has a close relationship to cancer formation,and need to pay more attention in the dialectic treatment.
出处
《中医药学刊》
CAS
2002年第3期296-297,共2页
Study Journal of Traditional Chinese Medicine
基金
国家自然基金资助课题 (89170 0 2 4)
