摘要
目的探讨影响胃癌患者长期生存的独立预后因素。方法采用Cox比例风险模型对可能影响胃癌患者预后的15个临床病理、治疗措施及分子生物学指标,进行多因素回归分析。结果单因素分析显示TNM分类、病期、肿瘤生长方式、淋巴管静脉侵犯、术前动脉插管介入化疗、术后腹腔化疗、CD44拼接变异体V6(CD44V6)和E-钙黏附素(E-CD)表达及增殖细胞核抗原标记指数(PCNALI)与胃癌患者术后生存率显著相关(P均<0.05)。Cox多因素回归分析显示,按作用强度、TNM分类、术前动脉插管介入化疗、术后腹腔化疗、肿瘤生长方式依次为影响胃癌患者长期存活的预后因素。结论TNM分类、术前动脉插管介入化疗、术后腹腔化疗、肿瘤生长方式为胃癌患者的独立预后因素。术前动脉插管介入化疗和术后腹腔化疗对改善胃癌患者的预后具有重要价值。
Objective To determine the independent prognostic factors of long term survival for gastric cancer after curative resection.Methods Eighty six patients who underwent curative resection for gastric cancer were included for univariate and Cox multivariate regression analysis.15 factors contributed to the long term survival were analyzed. Results The TNM classification, tumor stages, Ming′s tumor growth pattern, lymphatic and vessel invasion, preoperative intraarterial infusion chemotherapy, postoperative intraperitoneal chemotherapy, the expression of CD44V6 and E cadherin, PCNA LI were significantly correlated with survival rates by univariate analysis (P< 0 05). Multivariate analysis revealed that the TNM classification, preoperative intraarterial infusion chemotherapy, postoperative intraperitoneal chemotherapy and Ming′s tumor growth pattern were significant factors for long term survival. Conclusions TNM classification, preoperative intraarterial infusion chemotherapy, postoperative intraperitoneal chemotherapy and Ming′s tumor growth pattern are independent prognostic factors for gastric cancer. Preoperative intraarterial infusion chemotherapy and postoperative intraperitoneal chemotherapy may have important value for improving the prognosis of gastric cancer.
出处
《中华胃肠外科杂志》
CAS
2002年第2期113-116,共4页
Chinese Journal of Gastrointestinal Surgery
