摘要
目的:探讨比例风险模型(Cox模型)在中医药治疗胃癌疗效评价中的运用,研究健脾法为基础的中医药治疗对胃癌预后的影响作用.方法:采用单因素及Cox多因素回归分析了166例胃癌患者临床病理因素及治疗措施对预后的影响.结果:单因素分析表明,胃癌预后与肿瘤原发部位、临床病理分期、手术方式、化疗及健脾法为基础的中药胃肠安治疗相关.Cox多因素回归分析表明:临床病理分期、手术方式及中药胃肠安治疗是影响胃癌预后的独立因素.临床病理分期中以Ⅰ期为参照,Ⅱ期、Ⅲ期及Ⅳ期的相对危险度分别为0.091、0.038及0.303;手术方式中以根治术为参照,姑息切除术改道及探查术的相对危险度分别为0.054、0.128;中药胃肠安的相对危险度为3.575.而肿瘤原发部位、化疗则未显示为独立预后因素(P>0.05).结论:比例风险模型在中医药治疗胃癌的疗效评价中是适合和有价值的方法;健脾法为基础的中医药治疗是改善胃癌预后的有效干预措施.
AIM: To evaluate the effect of Chinese jianpi herbal recipe Wei Chang An (WCA) on the prognosis of gastric cancer. METHODS: Univariate and Cox regressions were applied to analyze the influence of the clinical, pathological and therapeutical variables on the prognosis of 166 gastric cancer patients. RESULTS: In univariate analysis, the significant prognostic factors were the site of the tumor, the TNM stage, surgery, chemotherapy and WCA. Multivariate analysis suggested that the TNM stage, radical resection, and WCA were independent prognostic factors. Patients who received WCA demonstrated better prognosis independent of other prognostic factors in multivariate analysis. The odds ratios [Exp(B)] of stage Ⅱ, Ⅲ and Ⅳ were 0.091 (95% CI: 0.028-0.294), 0.038 (95% Cl: 0.008-0.175) and 0.303 (95% Cl: 0.152-0.603), respectively. Exp(B) of WCA was 3.575 (95% Cl: 1.768-7.228). The site of the tumor and chemo- therapy had no influence on survival in multivariate analysis (P>0.05). CONCLUSION: Cox regression analysis is a proper statistical method for the evaluation of the effectiveness of Traditional Chinese Medicine therapy on gastric cancer. The Chinese jianpi herbal recipe WCA has important value for improving the prognosis of gastric cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2005年第9期1055-1058,共4页
World Chinese Journal of Digestology
基金
上海市科委青车科技启明星计划资助项目:No.02QB14043上海市教委研究基金资助项目
No.01C06~~
