摘要
目的 研究重症肺炎患者T淋巴细胞亚群的变化。方法 用荧光单抗CD3 + 、CD4 + 、CD2 5+ 、CD95+ 、CD3 + /CD2 5+ 、CD8+ /CD2 8-对淋巴细胞进行标记和计数。结果 重症肺炎患者体内CD3 + 、CD95+ 、CD3 + /CD2 5+ 减少 (P <0 .0 1,P<0 .0 5 ) ,CD4 + 、CD2 5+ 无明显变化 (P >0 .0 5 ) ,而CD8+ /CD2 8-增加 (P<0 .0 1)。结论 重症肺炎患者T淋巴细胞因大量凋亡而总数减少 ,亚群的变化又造成免疫功能紊乱 ,因此在临床治疗过程中需调整患者免疫功能。
Objectives To study on the change of subtype of T-lymphocyte in the critical cases with severe pneumonia. Methods The lymphocytes were marked and counted with mono antibodies CD 3 +?CD 4 +?CD 25 +?CD 95 +?CD 3 +/CD 25 +?CD 8 +/CD 28 -.Results In severe pneumonia cases,CD 3 +?CD 95 +?CD 3 +/CD 25 + were decreased(P<0.01,P<0.05),CD 4 +?CD 25 + had not obvious changes(P>0.05),CD 8 +/CD 28 - was increased(P<0.01).Conclusions In severe pneumonia cases,the total amount of T-lymphocyte decreased heavily as the result of great apoptosis,the immune functions was disordered due to the change of subtype of T-lymphocyte,therefore,the immune functions of the patients should be adjusted during the course of the clinical treatment.
出处
《宁夏医学杂志》
CAS
2002年第6期331-332,共2页
Ningxia Medical Journal
基金
浙江省科技厅资助项目 (0 1 2 1 1 6)
