摘要
目的 :研究甲状腺癌组织中CD44v6抗原的表达情况及其临床意义。方法 :应用微波—LSAB免疫组织化学法 ,检测 5 0例甲状腺癌、45例甲状腺腺瘤和 2 0例癌旁甲状腺组织中CD44v6的表达。结果 :在甲状腺癌中CD44v6表达阳性率为 6 4 0 % ,显著高于甲状腺腺瘤 (37 0 % )和癌旁甲状腺 (2 5 0 % ,P <0 0 5 )。CD44v6表达与甲状腺癌组织类型无关 ,在淋巴结转移病例和病理分期Ⅲ～Ⅳ期病例 ,CD44v6表达阳性率显著高于相应的无淋巴结转移病例和病理分期Ⅰ～Ⅱ期病例 (P <0 0 5 )。CD44v6阳性的甲状腺癌复发及死亡率显著高于CD44v6阴性的甲状腺癌复发和死亡率 (P <0 0 5 )。结论 :CD44v6表达对甲状腺癌恶性程度判断、生物学行为预测和预后评估是一种很有意义的客观指标。
Objective:To study the expression of CD44v6 in thyroid cancer and its significance.Methods:The expression of CD44v6 in 50 thyroid cancers,45 adenoma and 20 adjacent noncancerous portion tissue were respectively investigated by Microwave LSAB immunohistochemical technique.Results:The expression rate of CD44v6 in thyroid cancer was 64 0%,which was significantly higher than 25 0% in adjacent noncancerous portion and 37 0% in adenoma( P <0 05).No correlation was observed between expression of CD44v6 and histological grading of thyroid cancer.The expression of CD44v6 in lymph node positive and grade Ⅲ～Ⅳ were both higher than that in negative cases and grade Ⅰ～Ⅱ( P <0 05).The percentage of recurrence and death in CD44v6 positive cases were notably higher than that in negative cases( P <0 05).Conclusion:The expression of CD44v6 can be regarded as a parameter for evaluating the degree of malignacy,biological behavior and prognosis of thyroid cancer.
出处
《临床肿瘤学杂志》
CAS
2002年第2期94-96,共3页
Chinese Clinical Oncology
