摘要
目的 观察CD44V 6在肺癌中的表达及其与肺癌淋巴结转移的关系。方法 采用免疫组化S P法对 85例原发性肺癌进行免疫组化研究。结果 在小细胞肺癌 (SCLC)中 ,未见CD44V 6表达 ;在Ⅰ、Ⅱ、Ⅲ、Ⅳ期非小细胞肺癌 (NSCLC)中CD44V 6的阳性表达率分别为 30 .0 %、5 2 .4%、6 4.0 %和 84.2 %。Ⅲ、Ⅳ期和Ⅰ、Ⅱ期之间CD44V 6表达有非常显著性差异 (P <0 .0 1) ;Ⅳ期和Ⅰ、Ⅱ、Ⅲ期之间CD44V 6表达有显著性差异 (P <0 .0 5 )。肺癌伴淋巴结转移者的CD44V 6表达高于未发生淋巴结转移者 (χ2 =7.2 5 ,P <0 .0 1)。Ⅲ、Ⅳ期转移灶之间CD 44V 6表达无显著性差异 (χ2 =2 .2 7,P >0 .0 5 )。CD 44V 6表达与肺癌组织分化程度有关 ,与病理类型及临床参数无关。结论 CD 44V 6表达与肺癌分期密切相关 ,CD 44V 6阳性表达者易发生淋巴结转移 ,预后差。
Objective To observe the expression of CD44V6 and its association with lung carcinomas metastasis.Methods Paraffin embedded tissues from 85 cases of primary lung carcinomas and 15 cases of metastatic lymph nodes were investigated for expression of CD44V6 by immunohistochemistry(S P method).Results There was no expression in all 5 cases of SCLC.Positive rate of CD44V6 expression in stageⅠ、Ⅱ、Ⅲ and Ⅳ of non small lung carcinoma was 30.0%、52.4%、64.0% and 84.2%,respectively.There was a distinct statistical difference between stage Ⅰ、Ⅱ and stage Ⅲ、Ⅳ,between stage Ⅳ and stage Ⅰ、Ⅱ、Ⅲ( P <0.01, P <0.05).Primary lung carcinoma with lymph node metastasis showed higher expression of CD44V6 compared with that without lymph node metastasis(χ 2=7.25, P <0.01).There was no obvious difference in expressions of CD44V6 of metastasis lesion between stage Ⅲ and stage Ⅳ(χ 2=2.27, P >0.05).The expression of CD44V6 was associated with tumor differentiation,but didn't relate to pathological type and clinical parameter.Conclusion Expression of CD44V6 is associated with clinical stage of lung cancer;CD44V6 positive expression may suggest a potential of high risk for lymph node metastasis and poor prognosis.
出处
《实用癌症杂志》
2001年第1期27-28,56,共3页
The Practical Journal of Cancer
