摘要
目的 研究异亚丙基莽草酸 (ISA)对大鼠动静脉环路血栓、大脑中动脉栓塞及血小板聚集的对抗作用及机制。方法 用动静脉环路血栓及三氯化铁致大脑中动脉栓塞 (MCAT)模型观察药物作用 ;并研究了ISA体内、外给药对血小板聚集的影响。结果 ISA 2 5 ,5 0 ,10 0及 2 0 0mg·kg- 1 ig均可显著降低大鼠体外血栓重量 ;ISA 5 0 ,10 0 ,2 0 0mg·kg- 1 ig可明显改善MCAT模型大鼠神经症状 ;ISA 10 0及 2 0 0mg·kg- 1 igMCAT模型大鼠脑梗塞范围分别下降2 7 8%和 3 1 6% ;另外 ,ISA体内、外给药对ADP和胶原诱导的血小板聚集有明显的抑制作用。
AIM To study the effect of 3,4 oxo isopropylidene shikimic acid (ISA) against arteriovenous shunt and middle cerebral artery thrombosis (MCAT) in rats. METHODS Arteriovenous shunt model was adopted to measure thrombus weight; The neurologic deficit (ND) and the infarct size (IS) of the middle cerebral thrombosis (MCAT) model induced by FeCl 3 were observed; The effect of ISA on platelet aggregation rate of rat and rabbit by giving ISA in vivo and in vitro was studied. RESULTS ISA 25, 50, 100 and 200 mg·kg -1 ig was shown to reduced the weight of thrombus in arteriovenous shunt model; ISA 50, 100 and 200 mg·kg -1 ig for 2 times in 24 hours, attenuated the ND of rats subjected to MCAT; ISA 100 and 200 mg·kg -1 reduced IS of rats after MCAT by 27 8% and 31 6%, respectively; ISA 50, 100 and 200 mg·kg -1 ig inhibited platelet aggregation of normal rats; ISA 10 -3 ～10 -5 mol·L -1 , inhibited rabbit platelet aggregation in vitro . CONCLUSION ISA inhibited thrombosis by anti platelet aggregation.
出处
《药学学报》
CAS
CSCD
北大核心
2002年第4期245-248,共4页
Acta Pharmaceutica Sinica
基金
国家中医药管理局"十五"攻关项目 ( 2 0 0 1BA70 1A0 7-14 ) .
关键词
异亚丙基莽草酸
抗血栓作用
大脑中动脉
脑缺血
脑梗死
血小板聚集
实验研究
oxo isopropylidene shikimic acid
thrombosis
cerebral artery
cerebral ischemia
cerebral infarction
platelet aggregation
