摘要
以 3种给药途径在恒河猴体内进行青心酮生物利用度比较。实验结果表明 :青心酮在动物体内具有吸收快 ,消除快的特点 ,肌肉注射与灌胃给药的吸收半衰期在 0 .0 5～ 0 .0 7h之间 ,消除半衰期在 0 .14～ 0 .2 9h之间。肌肉给药 10mg/kg的剂量与静脉给药相同剂量的相对生物利用度为 94 .71%。灌胃给药 6 0mg/kg剂量与静脉给药 10mg/kg的剂量相对生物利用度仅为 9.16 %。
The in-vivo bioavailability of Qingxintong administrated by intramuscular injection, intravenous injection and gastric infusion was compared. Experimental results showed that Qingxintong was rapidly absorbed and excreted. The half-life time for absorption was 0.05 - 0.07 h and the half-life time for elimination was 0.14 - 0.29 h. The bioavailability of Qingxintong in the dose of 10 mg/kg by intramuscular injection or by intravenous injection was 94.71 %, and was 9.16% in the dose of 60 mg/kg by gastric infusion or in the dose of 10mg/kg by intramuscular injection.
出处
《中药新药与临床药理》
CAS
CSCD
2002年第1期31-32,共2页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
青心酮
药代动力学
高压液相色谱法
比较研究
Qingxintong/pharmacokinetics
@Qingxintong/analysis
Chromatography,high pressure liquid
