摘要
目的 探讨粘附分子-1(CD_(54))在直肠癌组织和邻近肠粘膜上皮的表达及其临床意义.方法 应用荧光标记的CD_(54)单克隆抗体分子探针,通过流式细胞仪检测,对36例直肠癌癌组织、癌下缘2cm处肠粘膜上皮及患者正常结肠上皮的CD_(54)表达进行了对比研究.结果 直肠癌细胞CD_(54)表达为(9.79±5.12)%,与癌下缘2cm处肠上皮无显著差异(P>0.05),但显著高于正常处结肠上皮和正常对照组(P<0.05).结论 CD_(54)肠癌组织明显表达,可作为直肠癌临床研究的指标;癌下2cm处肠上皮CD_(54)表达与直肠癌组织相似,提示有恶性转化的趋势.
Objective: To discuss the expresion of CD54 in rectal carcinoma and nearby epithelial cells and its clinical significance. Methods :The expressive contents of CD54 of the tumors and the epithelial cells 2cm away from the lesions and on the colon section margin were comparatively studied by flow immunocytometry in 36 cases with rectal carcinoma. Results: The CD54 expressive contents of rectal carcinomas were (9. 79 ± 5.12)%,similar to that of the epithelial cells 2cm distal away from the lesions (P>0.05) and more than that of colon section margins (P<0.05) and normal contrast groups. Conclusion : The CD54 were obviously expressed in both the rectal carcinoma and the epithe-lial cells 2cm distal away from the lesions. This suggests the parameter of CD54 may be used as an important clinical tumor marker for rectal carcinoma and the epithelial cells 2cm nearly the lesions may have the tendency for malignancy.
出处
《中国现代普通外科进展》
CAS
1999年第2期25-27,共3页
Chinese Journal of Current Advances in General Surgery
