摘要
芳醛、 5 ,5 -二甲基 -1 ,3-环己二酮、丙二酸亚异丙酯经微波辐射发生缩合、加成、环化及消去反应 ,一步合成了 7,7-二甲基 -4 -芳基 -2 ,5 -二氧代 -1 ,2 ,3,4 ,5 ,6,7,8-八氢喹啉和 7,7-二甲基 -4 -芳基 -5 -氧代 -3,4 ,5 ,6,7,8-六氢香豆素 ,反应在 3～ 5 min内完成 ,产率优良 .
A series of 4 aryl 7,7 dimethyl 2, 5 dioxo 1,2,3,4,5,6,7,8 octahydroquinoline (4) and 4 aryl 7,7 dimethyl 5 oxo 3,4,5,6,7,8 hexahydrocoumarin (5) were synthesized from aromatic aldehydes (1), 5,5 dimethyl 1,3 cyclohexandione (2) and isopropylidene malonate (3) by the condensation, addition, cyclization and elimination reactions under microwave irradiation under different conditions. The reactions were completed in 3-5 min with good yields. The structure of the products were established on IR, 1H NMR, elemental analysis and X ray diffraction.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2002年第2期222-225,共4页
Chemical Journal of Chinese Universities
