摘要
目的 探讨预防型抗氟剂中锌在体内的分布。方法 通过大鼠亚慢性试验 ,分析血清锌、铜水平变化及肝、肌肉、长骨、脑中锌、铜的分布情况。结果 给药 12周后 ,高剂量组血清锌及锌 /铜比值明显升高 ,但停药 4周后即下降到与对照组相近水平 ,进入体内的锌在脏器中的分布以肝、骨最高 ,肌肉、脑次之 ,停药 4周后肝脏中锌及锌 /铜比值明显下降到与对照组相近水平 ,骨、肌肉中锌及锌 /铜比值虽见下降 ,但其锌含量仍保持在较高水平。结论 预防型抗氟剂对消除过量氟对机体锌代谢的影响 ,提高机体锌含量水平具有一定意义。
Objective Distribution of zinc of anti fluorine agent in animal body was studied.Methods By sub chronic experiment in rats,changes of Cu and Zn in serum and their distribution in liver,muscle,bone and brain were detected.Results Serum Zn and Zn/Cu in high dose group increased significantly after taking medicine for 12 weeks,but when administration stopped for 4 weeks,they dropped to a level same as the controls.Zinc mainly distributed in liver and bone,secondly in the muscle and brain.After administration stopped for 4 weeks,Zn and Zn/Cu in liver dropped to a level same as the controls.Although Zn and Zn/Cu in bone also dropped,the content of Zn remained relatively high.Conclusions It suggested that preventive anti fluorine agent may play some role in eliminating excessive fluorine on the metabolism of zinc and raising the content of zinc in body.
出处
《工业卫生与职业病》
CAS
CSCD
北大核心
2001年第5期279-282,共4页
Industrial Health and Occupational Diseases
基金
国家"九 五"攻关项目资助 ( 96 -90 6 -0 4-0 2 -10 )
