摘要
目的 观察强化锌奶粉和不同含锌量的饲料对小鼠造血系统的影响。方法 昆明小鼠３６ 只按体重随机分为４ 组（ 对照组、奶粉组、等量锌组、高锌组） ，分别饲以含强化锌奶粉饲料和不同含锌量的饲料２４ 周。结果 ①高锌组喂养１２ 周后血红蛋白（Ｈｂ） 降低（与对照组相比Ｐ＜０ ．０５） ，１６ 周时进一步下降（ Ｐ＜ ０．０１）。２４ 周时Ｈｂ、ＲＢＣ、ＨＣＴ、ＭＣＶ 均明显下降（ Ｐ＜ ０．０１），中性粒细胞绝对值下降（Ｐ＜０．０５），骨髓幼红细胞增生。血清及肝、肾中锌含量增加但铜含量下降，血清铜蓝蛋白下降。②奶粉组１６ 周时各项指标无明显变化，２４ 周时变化与高锌组相似。２４ 周时等量锌组小鼠肝、肾铜含量轻度降低（Ｐ＜０ ．０５） 。结论 高锌摄入可导致贫血，一般情况下，食用强化锌奶粉是安全的，但长期超量食用可干扰造血系统。
Objective To observe the effect of Zn intensified milk powder and zinc on hematopoiesis in mice. Methods Kunming mice were randomly divided into four groups (n=9 each) (control group; milk powder group; equal zinc group; high zinc group) and fed on experimental diet for 24 weeks.Results ①In high zinc group: the mice hemoglobin (Hb) declined (P<0.05) after 12 wk of supplementation and were significantly lower (P<0.01)than those in control group at 16 wk. At 24 wk, the mice showed lower Hb, red blood cell(RBC), hematocrit (HCT), and mean corpuscular volume (MCV) compared with control group (P<0.05). Bone marrow aspirates revealed erythroid hyperplasia. Zinc concentrations in serum, liver and kindney were higher (P<0.01) and copper was lower than that of control group(P<0.01). ②At 16 wk, no change occurred in milk powder group and equal zinc group. At 24 wk, parameters changed in milk powder group similar to those in high zinc group, and in equal zinc group liver and kindney copper was lower than that in control group (P<0.05). Conclusion Ingestion of over dosed zinc could induce anemia. Generally, intake of Zn intensified milk powder is safe, but long term intake of the milk powder may interfere with hematopoiesis. Key words Mice Hematopoietic system Anemia Zinc欤? ｄｒａｗ ａ ｃｏｎｃｌｕｓｉｏｎ ｔｈａｔ ｔｈｅ ｃｏｎｃｏｍｉｔａｎｔ ｓｔｒａｂｉｓｍｕｓ ｓｕｒｇｅｒｙ ｗａｓ ｍｏｓｔ ｃｏｍｍｏｎ ｓｕｒｇｅｒｙ，ｅｓｐｅｃｉａｌｌｙ ｔｈｅ ｃｏｎｃｏｍｉｔａｎｔ ｅｘｏｔｒｏｐｉａ ｓｕｒｇｅｒｙ．
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1999年第12期643-645,共3页
Chinese Journal of Hematology
