摘要
目的 :探讨恶性血液病 p2 1WAF1、CyclinE(细胞周期素E)的表达及其临床意义。 方法 :应用免疫组化SP法检测 79例恶性血液病患者的 p2 1WAF1和CyclinE的表达情况 ,同时结合临床其他资料进行分析。 结果 :p2 1阳性表达 2 7例 (34.2 % ) ,显著低于正常对照组 (P <0 .0 1) ;CyclinE阳性表达 5 5例 (6 9.6 % ) ,显著高于正常对照组 (P <0 .0 1) ;P2 1与CyclinE的表达相互之间存在明显负相关 (r =- 0 .31,P <0 .0 5 ) ;p2 1和CyclinE的表达与恶性血液病分化程度明显相关 (P <0 .0 1和P <0 .0 5 )。结论 :p2 1和CyclinE在恶性血液病中的异常表达与其发生发展密切相关 。
Objective:To explore the expression of p21 WAF1 and Cyclin E and their clinical significance in malignant hematopoietic diseases.Method:SP immunohistochemistry technique was used to examine the expression of p21 WAF1 and Cyclin E in 79 patients with acute leukemia and Non-Hodgkin′lymphoma (39 and 40 patients,respectively).The association of p21 and Cyclin E status with some clinical materials was also investigated.Result:27 patients ( 34.1 %) were positive for p21, which was significantly lower than normal control group (P< 0.01 ) ;55 cases ( 69.6 %) were positive for Cyclin E,which was significantly higher than normal control group (P< 0.01 ) ; There was negative correlation between p21 and Cyclin E expression (r=- 0.31 ,P< 0.05 ) ;There was significant difference in the expression of p21 and Cyclin E and the maliganancy of the patients (P< 0.01 ;P< 0.05 ,respectively).Conclusion:The abnormal expression of p21 and Cyclin E is closely related to the development and progression of malignant hematopoietic diseases.Their expression in malignant hematopoietic diseases have predictive value.
出处
《临床血液学杂志》
CAS
2001年第6期250-252,共3页
Journal of Clinical Hematology
