摘要
目的探讨细胞周期素E在直肠癌中的表达及意义。方法应用免疫组织化学法检测42例直肠癌组织中细胞周期素E的表达情况，结合临床病理学资料进行统计学分析。结果细胞周期素E在直肠癌组织中的阳性表达率为66．7％（28／42）。直肠癌组织中细胞周期素E的阳性表达率与性别、年龄、分化程度、pTNM分期、淋巴结转移均无相关性（P〉0．05）。结论细胞周期素E可能与直肠癌的发生、发展有密切关系。细胞周期素E与直肠癌患者的年龄、性别、分化程度、pTNM分期、淋巴结转移无相关性。
Objective To investigate the expression and significance of cyclin E in rectum carcinoma. Methods The expression of cyclin E was examined by immunohistochemieal techniques in 42 cases of rectum carcinoma. Laboratory data were then analyzed statistically together with the related clinical and pathological data. Results The positive expression rate of eyclin E in rectum carcinoma was 66.7% （28/42）. There was no significant association between cyclin E and gender,age,histological grade,pTNM stage, metastasis of lymph node （P 〉 0.05 ）. Conclusions The expression of cyclin E in rectum carcinoma is higher, and it may show highly associated with the occurrence and development of the rectum carcinoma. Cyclin E has no significant association with age, gender, histological grade, pTNM stage, metastasis of lymph node.
出处
《中国医师进修杂志》
2013年第3期30-32,共3页
Chinese Journal of Postgraduates of Medicine
