摘要
目的 探讨乳腺癌患者血清中肿瘤坏死因子 (TNF α)和白细胞介素 (IL 6 )的变化及临床意义。方法 采用ELISA法测定 48例乳腺癌患者和 35例健康对照人血清中TNF α和IL 6水平 ;结果 乳腺癌患者TNF α和IL 6活性水平均高于健康组 (P <0 0 1) ,乳腺癌未手术患者 (伴骨转移 )TNF α和IL 6水平均高于术后复发者 (P <0 0 5 )。结论 血清中TNF α和IL 6活性水平可能与乳腺癌发生、发展有关。测定其水平可作为临床病情观察和监测疗效的辅助手段。
AIM\ To study the change and clinical implication of tumor necrosis(TNF-α) and interleukin-6(IL-6) in the breast cancer patients. METHODS\ Serum TNF-α and IL-6 level in 48 of breast cancer cases and 35 of normal control group were measured by ELISA. RESULTS\ Serum TNF-α and IL-6 level were significantly higher in the breast cancer patients than in normal control group ( P <0 01). The activity of TNF-α and IL-6 in serum of the no operational patients (bone transferring patients) was higher than the recurrent patients of post-operation ( P <0 01). CONCLUSION The activity of serum TNF-α and IL-6 may related with development of the breasr cancer. The determination of TNF-α and IL-6 in serum could help to obsevation of the breast cancer state as a supplementary methods.
出处
《安徽医药》
CAS
2001年第2期118-119,共2页
Anhui Medical and Pharmaceutical Journal
