摘要
目的 探讨肺癌患者血清中肿瘤坏死因子 (TNF α)和白细胞介素 (IL 6 )的变化及临床意义。方法 采用ELISA法测定 5 5例肺癌患者和 40例健康对照人血清中TNF α和IL 6水平。结果 肺癌患者TNF α和IL 6活性水平均高于健康组 (P <0 0 1) ,肺癌未手术患者 (伴淋巴结转移 )TNF α和IL 6水平均高于术后复发者 (P <0 0 5 )。结论 血清中TNF α和IL 6活性水平可能与肺癌发生、发展有关。测定其水平可作为临床病情观察和监测疗效的辅助手段。
Objective To study the change and clinical implications of tumor necrosis(TNF-α) and interleukin-6(IL-6) in the lung cancer patients. Methods Serum TNF-α and IL-6 level in 55 of lung cancer cases and 40 in normal control group were assayed by ELISA. Results Serum TNF-α and IL-6 level were significantly higher in the lung cancer patients than in normal control(P<0.01). The activity of TNF-α and IL-6 in serum of the no operational patients (with lymphanode matastasis) was higher than the recurrent patients of post-operation (P<0.01). Conclusion The activity of serum TNF-α and IL-6 may be associated with development of the lung cancer. The determination of TNF-α and IL-6 levels in serum can help to observe the lung cancer state as a assistant monitor methods.
出处
《安徽医科大学学报》
CAS
2001年第1期45-46,共2页
Acta Universitatis Medicinalis Anhui
关键词
肺肿瘤
血液
肿瘤坏死因子
白细胞介素6
lung neoplasms/blood
tumor necrosis factor/analysis
interleukin-6
