摘要
目的 检测术前区域动脉灌注化疗 ,以及行根治手术后结直肠癌组织中 PD- ECGF蛋白的表达水平。探讨术前区域动脉灌注化疗对肿瘤组织中 PD- ECGF蛋白表达及肿瘤血管生成的影响。方法 通过免疫组织化学方法 ,测定术前区域动脉化疗后 30例结直肠癌组织中 PD- ECGF的表达水平 ,并与同期未行术前动脉化疗的 31例结直肠癌组织作比较。结果 术前动脉化疗组的肿瘤组织中 PD- ECGF的表达较对照组低 ,差异有显著性 (P<0 .0 5 )。患者的性别、年龄、肿瘤的大体病理类型、部位、大小、分化程度与 Dukes分期等临床病理因素对 PD- ECGF的表达差异均无显著性。结论 结直肠癌术前区域动脉灌注化疗可能通过抑制肿瘤细胞分泌 PD- ECGF蛋白 ,从而减少肿瘤的血管生成及肿瘤细胞的供氧 ,改善结直肠癌患者的治疗效果和预后。
Objective To detect the expression of PD-ECGF in tissue specimens of patients with colorectal cancer who had received preoperative regional intraarterial chemotherapy (PRAC).Methods The expression of PD-ECGF were examined by immunohistochemistry method in cancerous tissues from 30 patients with colorectal concer who received PRAC and from 31 patients without PRAC.Results The expression of PD-ECGF protein in PRAC group was remarkably lower than that in the control group (P<0.01) and not correlated with Dukes stage, tumor size,tumor location,etc.Conclusion PRAC may down regulate the expression of PD-ECGF to reduce tumor angiogenesis and to inhibit the proliferation of cancer cells.;
出处
《实用肿瘤杂志》
CAS
北大核心
2001年第6期388-390,共3页
Journal of Practical Oncology
