摘要
15例大肠癌患者接受切除术,术中并用5-氟尿嘧啶(5-FU)肠腔灌注化疗;同时用微生物法测定肠系膜静脉血和周围静脉血液中的5-FU浓度。结果表明15例肠系膜静脉血于灌注后15分钟和30分钟5-FU浓度分别为222±79μg/ml和110±26μg/ml,而在周围静脉血除2例检测出极低的药物浓度(1.3μg/ml和1.4μg/ml)外,其余13例均未能检出5-FU。由此可见,肠腔灌注5-FU后,很快就被肠壁吸收,使局部静脉血液内抗癌药在短时间内达到高浓度而周围静脉血中几乎测不出,这样就不必过多考虑全身毒性问题,而局部高浓度抗癌药可以杀死术中脱落的癌细胞,并阻止其经血道转移。
From March to December 1986 fifteen patients patients with largebowel cancer were admitted and underwent resection. During the operation intrsluminal infusion of fluorouracil (5 -FU) was used and blood drug concentrations in mesenteric and peripheral veins were assayed.In all cases the dlood 5- FU concentrations in mesenteric veins 15 and 3 0 minutes after intraluminal infusion of 5-FU (30mg/ kg body weight) were 222 ±79μg/ml and 1 10 ±26 μg/ml, respectively. But the blood 5 -FU concentrations in peripheral veins were zero in 13 cases and very low(l.3μg/ml-1.6μg/ml) in 2 cases. The results showed that intar luminal 5-FU is quickly absorbed by the bowel wall, so that the anticancer drug reaches high concentration in the blood of regional veins in a short time, but can not bedetected in the blood of peripheral veins. Therefore, systematic toxieity may not be considered, while the high concentration of anticancer drug in the local sate may kill the cancer cells fallen into the blood stream during operation and thus prevent them from metastasis.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1990年第3期189-191,263,共4页
Chinese Journal of Cancer
