摘要
目的探讨术前动脉灌注化疗对直肠癌细胞凋亡的影响。方法采用末端脱氧核苷酸转移酶介导缺口末端标记(TUNEL)法对45例术前动脉灌注化疗(研究组)和47例单纯根治性切除术(对照组)患者的术后标本进行细胞凋亡的检测。结果研究组细胞凋亡指数比对照组明显增高,两组的细胞凋亡指数分别为(56.7±15.3)%、(36.5±14.6)%;研究组局部复发和肝转移发生率均明显低于对照组,其术后5、10年生存率也显著高于对照组。结论术前动脉灌注化疗可能通过调节直肠癌细胞凋亡影响预后。
Objective To expore the influence of preoperative intraarterial infusion chemotherapy on apoptosis of rectal carcinoma cells and its implication. Methods 45 patients were treated with preoperative intraarterial infusion chemotherapy and 47 with operation served as the control group. Apoptosis was analyzed by terminal deoxynucleotidyl-transferase mediated dUTP-biotin nick ending la beling （TUNEL）. Results The apoptosis index of the preoperative chemotherapy group was significantly higher than that of the control group [（56.7±15.3）% vs （36.5±14.6）%]. Recurrence rate and liver metastasis rate of the preoperative chemotherapy group were significantly lower than those of the control group. 5-, 10- year survival rate were significantly higher than the control group （ P〈0. 05）. Conclusions Apoptosis may be one of the most important mechanism for anticancer effect of preoperative intraarterial infusion chemotherapy.
出处
《消化外科》
CAS
CSCD
2005年第5期357-359,共3页
Journal of Digestive Surgery
关键词
直肠肿瘤
药物疗法
输注
动脉内
细胞凋亡
预后
rectal carcinoma drug therapy infusion, intraarterial apoptosis prognosis
