摘要
目的 :探讨营养不良、肾病本身和糖皮质激素对大鼠生长、食物效率及血清GH浓度的影响。方法 :2 4只周龄相同体重相近的雄性SD大鼠被随机分成正常、食物对照、阿霉素 (5mg/kg)肾病和地塞米松 (1.8mg/kg·d)治疗肾病四组。按常规测量摄食量、体重、鼻 -尾长度和血清GH浓度 ,计算生长速率和食物效率并进行比较。结果 :肾病组大鼠摄食量低于正常组 ,激素治疗组低于肾病组。肾病组大鼠生长速率和食物效率均低于食物对照组 ,激素治疗组低于肾病组 ,但食物对照组除生长速率低于正常组外 ,食物效率两组相同 ;食物对照组大鼠血清GH浓度增高 ,肾病组正常 ,激素治疗组低于肾病组。结论 :除继发性营养不良和糖皮质激素治疗外 ,肾病本身也是引发NS生长障碍的重要因素 ;
Objective:To investigate the effects of malnutrition,nephrosis itself and glucocorticoid therapy on growth,food efficiency and serum growth hormone(GH).Methods:Twenty-four male Sprague-Dawley(SD) rats were randomly divided into control,pair-fed,doxorubincin-induced nephrotic(nephrotic)and dexamethasone-treated nephrotic (des-treated) rats.Food intake,nose-tail length,weight and serum GH were measured,growth rate and food efficiency were caculated.Results:1.Food intake was lower in nephrotic rats than in control,and in des-treated rats than in nephrotic rats.2.Both growth rate and food efficiency were slower in nephrotic rats than in control,and in des-treated ras than in nephrotic rats,but food efficiency was same between control and pair-fed rats except that growth rate was decreased in pair-fed rats.3.Serum GH was increased in pair-fed rats compared with control,reduced in des-treated rats compared with nephrotic rats,but no significant difference was found between nephrotic rats and control.Conclusions:1.Growth failure is caused by secondary malnutrition and nephrosis itself in nephrotic rats,and deteriorated by glucocorticoid therapy.2.Only glucocoticoid therapy may induce growth failure through reduced serum GH.
出处
《中国现代医学杂志》
CAS
CSCD
2001年第8期39-40,共2页
China Journal of Modern Medicine
基金
湖南省自然科学基金资助课题 [湘科计字 ( 97) 37号 -17]
关键词
生长障碍
肾病综合征
生长激素
Growth Failure
Nephrotic Syndrome
Growth Hormone
