摘要
目的 :总结儿童肾移植的效果及经验。方法 :回顾性分析 6例 16岁以下儿童肾移植的临床资料。结果 :血肌酐恢复正常时间为术后 1～ 6d ,平均 3d。术后 30d内发生急性排斥反应 (AR) 3例 ,抗排斥治疗后均逆转。移植肾均存活 2年以上 ,最长 1例已存活 13年。肾移植后身高未出现明显的加速生长现象。结论 :儿童肾移植的手术方式、补液及免疫抑制方法均需注意儿童的特殊性。AR在儿童肾移植中发生率相当高 ,如何预防及逆转AR是提高移植肾存活率的关键。生长障碍仍是影响移植效果的重要因素。
Objective:To summarize the outcome and experience of pediatric kidney transplantation.Methods:6 patients with kidney transplantations aged 9 to 16 years were retrospectively analysed.Results: Clinical data were as follows: Serum creatinine returned to normal level within 1-6 days (mean=3days) after transplantation. 3 patients experienced an acute rejection episode at 30 days after transplantation. All rejections were reversed after antirejection therapy. All grafts survived more than two years and the longest graft survival was 13 years by the latest follow-up. No patients showed a marked catch-up growth after transplantation.Conclusion:The surgical technique, fluid supplementation and immunosuppressive therapy were different from adult patients and should be tailored to the characteristics of children in pediatric kidney transplantation. Acute rejection is a frequent event in pediatric transplantation. How to prevent and reverse an acute rejection is critical to the survival of kidney graft. Growth retardation after transplantation continue to be problematic and affect the outcomes of renal transplantation.[FK(WB80011?6]
出处
《温州医学院学报》
CAS
2002年第3期148-149,152,共3页
Journal of Wenzhou Medical College
关键词
肾移植
儿童
移植物排斥
移植物存活
生长障碍
kidney transplantation
child
graft rejection
graft survival
growth disorders
