摘要
目的 探讨铁路乘警血浆热应激蛋白 (HSP) 6 0、HSP70、HSP90α和HSP90 β抗体与高血压之间的关系。方法 应用改进的酶联免疫反应技术测定血浆中热应激蛋白抗体的滴度。结果 182名铁路乘警血浆HSP6 0、HSP70、HSP90α和HSP90 β抗体的总阳性率分别为 5 .5 %、2 2 .0 %、8.2 %和 10 .4% ;高血压组 (以 140 /90mmHg为标准 ,1mmHg =0 .133kPa)乘警血浆HSP70抗体 1∶10阳性率 (4 0 .9% )比对照组 (15 .9% )升高 ,差异有显著性 (P <0 .0 5 ) ,其他抗体阳性率也升高 ,但差异无显著性 (P >0 .0 5 ) ;以 16 0 / 95mmHg为标准 ,4种HSP抗体阳性比例也轻度升高 ,但差异无显著性 (P >0 .0 5 ) ;按年龄分层并以 140 / 90mmHg为标准 ,30岁以上年龄段HSP70抗体阳性率较对照组均增加 ,但仅 5 0～ 5 9岁组与对照组比较 ,差异有显著性 (P <0 .0 5 )。
Objective To explore the relationship between plasma antibodies to main heat stress proteins and hypertension in railway policemen. Method Plasma antibodies to heat stress proteins were determined with improved ELISA. Results Total positive rate of antibodies to heat stress proteins(HSP60,HSP70,HSP90α and HSP90β) were respectively 5.5%,22.0%,8.2% and 10.4%.The positive rate of antibody against heat stress protein 70 (1∶10) increased significantly in hypertension group (based on criteria of 140/90 mm Hg,1 mm Hg=0.133 kPa) than in the control ( P <0.05),while the other antibodies to HSP60,HSP90α,HSP90β increased slightly ( P >0.05).On the criteria of 160/95 mm Hg,positive rates of all the four antibodies in hypertension group were higher but not to a significant level.When grouped by age and under 140/90 mm Hg,the percentage of antibody to HSP70 increased in those over 60.However,remarkable difference was observed only when comparing 50～59 year old group with the control( P <0.05)). Conclusion Plasma in those antibody to HSP70 may be involved in the development of hypertension.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2001年第5期363-365,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
铁路乘警
热应激蛋白70抗体
高血压
Railway policemen
Antibodies to heat stress proteins 70
Hypertension
