摘要
目的 探索治疗烧伤患者免疫功能低下的新方法。 方法 用无血清培养法培养CD3AK细胞 ,治疗大面积烧伤患者 ,类似患者另设对照组进行普通治疗 ,观察不同时相点两组患者的细胞免疫指标变化。 结果 同对照组相比 ,经体外培养的CD3AK细胞治疗后 ,患者T细胞亚群中CD4细胞比例升高 ,CD8细胞比例下降 ,CD4/CD8细胞比值升高。血清可溶性白介素 2受体水平下降 ,T淋巴细胞转化活性增强 ,NK细胞活性增强。 结论 无血清培养法培养的CD3AK细胞 ,能改善烧伤患者细胞免疫功能低下的状态 ,促进细胞免疫功能恢复。
Objective To explore new ways of correcting postburn immune suppression in severely burned patients. Methods CD3AK cells were cultured in serum-free medium and were employed to treat patients with major burns.Similar patients treated by routine treatment were set to be control group.The changes of cellular immunological indices were dynamically observed in the patients of two groups at different time points. Results Compared to those in control group,the ratio of CD4+ cell of T cell subgroup increased in patients treated by CD3AK,in concomitant with the decrease of the ratio of CD8+ cells and the increase of the ratio of CD4/CD8.Serum soluble IL 2R level decreased.T lymphocyte transforming activity increased and NK cell activity increased. Conclusion CD3AK cells cultured in serum free medium could improve and restore the decreased cellular immune function in burn patients. [
出处
《中华烧伤杂志》
CAS
CSCD
2001年第3期159-162,共4页
Chinese Journal of Burns
基金
江西省科委Ⅱ级课题资助项目 (F96 0 5 0 1)
