摘要
目的 :研究双氯芬酸钠 -乙基纤维素固体分散物颗粒及其缓释胶囊的药物释放动力学特性。方法 :测定不同粒径、不同浓度的双氯芬酸钠 -乙基纤维素固体分散物颗粒及其缓释胶囊在 p H6 .8磷酸盐缓冲液中的释放曲线 ,以零级动力学方程、一级动力学方程及 Higuchi方程分别对释放曲线进行拟合 ,根据所得方程的相关系数 ,探讨不同粒径、不同浓度的固体分散物颗粒及其缓释胶囊的释放特性。结果 :固体分散物颗粒释放动力学拟合优劣顺序为 :Higuchi模型方程、一级动力学方程、零级动力学方程 ;缓释胶囊释放动力学拟合结果的优劣顺序为 :Higuchi模型方程、零级动力学方程、一级动力学方程。结论 :不同浓度、不同粒度的双氯芬酸钠 -乙基纤维素固体分散物颗粒及缓释胶囊释放均遵从 Higuchi方程 。
Objective: To study the release kinetics and release m echanisms of diclofenac sodium(DS)-ethylcellulose (EC) solid dispersion granule s and sustained-release capsules. Methods: The dissolution curves of DS-EC sol id dispersion granules and sustained-release capsules were determined in pH6.8 PBS. The release data fitted with three model equations: zero-order kinetic, fi rst-order kinetic and Higuchi kinetic model. The release kinetics of granules a nd sustained-release capsules were judged by the sequences of correlation coeff icients of three model equations, respectively. Results: From good to bad, the s equence of fitness of granules dissolution model was: Higuchi model, first-orde r model, zero-order model, that of sustained-release capsules was: Higuchi mod el, zero-order model, first-order model. Conclusion: The releases both of DS- EC solid dispersion granules and sustained-release capsules were matrix diffusi on mechanism, respectively, following Higuchi equation.
出处
《天津药学》
2001年第4期31-33,共3页
Tianjin Pharmacy
