摘要
目的以壳聚糖为载体制备丹酚酸微囊,并对其体外释药模式进行研究。方法以收率和载药量为指标,考察处方及工艺因素对微囊的影响,并对处方和工艺进行优化。结果壳聚糖质量浓度1.5%,丹酚酸与壳聚糖的质量比1∶3,进风温度190℃,蠕动泵速度300mL.h-1,所制得的微囊表面圆整,载药量为25.99%,收率为51.88%,包封率为86.21%,平均粒径为105.6nm。体外具有一定的缓释特性,在0～240min内拟合一级释药模型方程ln(1-Q)=-0.236 9 t+4.591 7,r=0.920 3。结论采用喷雾干燥法制得的丹酚酸微囊,收率和载药量较高,制备工艺简单,可望成为实现中药微球工业化的有效方法。
Objective To prepare salvianolic acid-chitosan microcapsule and to investigate the drug release behavior in vitro.Methods Microcapsule were prepared using the spray drying method.The loading capacity and product yield were used to evaluate the influences of different formulations and preparation factors,the formulation was optimized by L9（34） orthogonal design.Results The optimal formulation and preparation factors were as follows： chitosan concentration（1.5%）,ratio of chitosan to salvianolic acid（1∶3）,inlet temperature（190 ℃）,air flow rate（300 mL·h-1）.The optimized microcapsule had a spherical shape,the loading capacity was 25.99 %,product yield was 51.88 %,the average diameter was 105.63 nm.The drug release profile in vitro could be described by One order kinetics ln（1-Q） =-0.236 9 t ＋ 4.591 7（r=0.920 3） at 0~240 min,which showed the prepared microcapsule had the sustained release effect.Conclusion The loading capacity and product yield of salvianolic acid microcapsule are higher,the preparation method is simple,and the process is stable.It will provide the basis for realizing the industrialization in Chinese materia medica microcapsule.
出处
《中国海洋药物》
CAS
CSCD
北大核心
2012年第5期27-31,共5页
Chinese Journal of Marine Drugs
基金
重庆市自然科学基金计划重点项目(海洋多糖用于丹参口服缓释微囊的研究CSTC
2009BA5034)资助
关键词
丹酚酸
壳聚糖
工艺
微囊
喷雾干燥法
salvianolic acid
chitosan
technology
microcapsule
spray drying
