摘要
目的 观察家兔肝脏高剂量率组织间插植内照射后肝纤维化的过程。方法 将家兔分成 4组 :A组 10Gy、B组2 0Gy、C组 30Gy、D组对照组 ,观察内照射后 1周、2周、1月、3月、6月的组织形态变化。 结果 30Gy内照射后半年逐渐出现肝纤维化病变 ,可分为急性放射性肝炎期 (1～ 2周 ) ;肝纤维化前期 (1～ 3个月 ) ;肝纤维化期 (6个月后 )。结论 照射后 6个月 10Gy组肝损伤基本恢复 。
Objective To observe liver fibrosis after rabbit liver interstitial brachytherapy.Methods The animals were divided into 4 groups at random. The animals in group A C were irradiated by interstital brachytherapy with 10Gy,20Gy,30Gy at reference dose point respectively, group Dis the control group. In each group, some animals were taken histopathological and ultrastructural examination, Van Gieson Aniline Blue Stain. after irradiated 1 week, 2 weeks, 1 month, 3 months, 6 months. Results In 30Gy group classic irradiation liver fibrosis has been appeared after irradiation half a year. It divided into three stages:acute irradiation hepatitis after irradiation 1 month; Pre liver fibrosis after irradiation 1~3 months; classic irradiation liver fibrosis after irradiation 6 months.Conclusion after irradiation 6 months, liver damage of 10Gy group has been essential recovered, classic irradiation liver fibrosis has been appeared at 30Gy group.
出处
《重庆医学》
CAS
CSCD
2001年第5期411-412,共2页
Chongqing medicine
关键词
内照射
肝纤维化
病理
放射性肝纤维化
intersitial brachytherapy
liver fibrosis
histopathollgcal
