摘要
经６０Ｃｏγ线照射大鼠肝区，通过光镜（常规ＨＥ染色，肝细胞内糖原染色、胶原纤维及网状纤维染色）、电镜和图像分析仪，定量研究了照后１年肘脏的病理改变。结果表明，３０Ｇｙ组在照射后１年内逐渐发生了放射性肝纤维化病变。在肝纤维化发生过程中，肝细胞内糖原颗粒含量进行性减少，间质中胶原纤维含量进行性增加，网状纤维于照射后１～３个月呈进行性增加。照射后６个月因肝细胞坏死、肝索塌陷，网状纤维呈减少趋势。
By means of optic microscope (HE,PAS,collagenous and reticular fiber staining),electron microscope and image analysis,the liver lesions within one year after local irradiation with 60 Co γ rays were studied quantitatively and dynamically.The results showed that hepatic radiation fibrosis occurred in 30 Gy irradiatied rats.In the course of fibrosis,the granules of glycogen in hepatocytes were decreased progressively;the collagenous fiber progressively increased;reticular fibers significantly increased in 1 3 months after irradiation and decreased after 6 months due to necrosis of hepatocytes and collapse of hepatic cell cords.The significance of quantitative changes in the formation of hepatic radiation fibrosis is discussed.
出处
《军事医学科学院院刊》
CSCD
北大核心
1996年第1期36-39,共4页
Bulletin of the Academy of Military Medical Sciences
关键词
辐射损伤
肝硬变
肝细胞
糖原
胶原
网状纤维
radiation injury,experimental
liver cirrhosis,experimental
animal,laboratory
glycogen
collagenous and reticular fiber
image analysis
