摘要
目的 :研究破伤风类毒素聚乳酸微球 (TT MS)的体外释放规律 ,考察附加剂对药物释放的影响。方法 :破伤风类毒素聚乳酸微球体外释放试验进行了 84d ,测定释放量 ,考察 :(1)聚乳酸平均相对分子质量 ;(2 )微球载药量 ;(3)微球粒径 ;(4 )附加剂对药物释放的影响。结果 :破伤风类毒素聚乳酸微球体外释放有显著的长效作用 ,释放模型为零级释放 ,释放速度与前面提到的 4种影响因素直接相关。结论
To study on in vitro release of tetanus toxoid contained in polylactide microspheres and the influence of additives on the drug release. Methods: Some parameters affecting the rate of release were assessed during the in vitro experiments lasted 84 days: (1)the molecular mass of the polymers, (2)the protein loading of the microspheres, (3)the particle sizes, (4)co encapsulation of additives. Results: The polylactide microspheres containing tetanus toxoid presented considerable sustained release effect. Release kinetics of the microspheres fitted in with zero order equations. The rate of release was shown to depend on the four parameters mentioned above. Conclusion: The polylactide microspheres investigated may be prospective for the development of controlled release vaccines.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2001年第3期228-232,共5页
Journal of Peking University:Health Sciences
基金
国家自然科学基金!(39770 878)资助&&
