摘要
目的 探讨治疗直肠癌简单 ,安全有效的辅助化疗方法。方法 113例直肠癌患者随机分为试验组 (T组 ) :术前 5 Fu 2 5 0～ 5 0 0mg ,保留灌肠 ,每晚 1次 ,共 10d。术后 1周 ,给予 5 Fu 5 0 0mg/M2 ,CF(甲酰四氢叶酸钙 ) 30mg或 30 0mg/M2 ,静注 ,每日 1次 ,共 5d ,以后每月 1次 ,共 5～ 6次 ;对照组 (C组 ) :术前单用 5 Fu 5 0 0mg/M2 ,静注 ,每日 1次 ,共 5d ,术后 1周再用 5 Fu5 0 0mg/M2 ,静注 ,每日 1次 ,共 5d ,以后每月 1次 ,共 5～ 6次。随访 5年 ,完全随访率 6 9.9%。结果 两组在 3年生存率 ,术前血象改变无显著性差异 ,而 5年生存率 ,术后复发率和术后感染率有显著性差异。结论 术前 5 Fu保留灌肠和术后 5 Fu/CF化疗可提高
Objective To evaluate the effect of a new adjuvant preoperative and postoperative chemotherapy on patients with rectal cancer.Methods 113 patients with rectal cancer consisted of two groups: T group (n=55), 5 Fu (5 fluorouracil)10 20 ml,keep down clysis qn,for ten times before opretion.5 Fu 500 mg/ m 2 ,CF(Leucovorin) 30mg/m 2 or 300 mg/m 2,iv qd for five times one week after operation;C group(n=58), 5 Fu 500 mg/m 2,iv.for five times befor surgery.5 Fu 500 mg/m 2 iv qd for five times one week after surgery.Results 3 years surivival rates,the counts of WBC. 16pc.were not statistically different between two groups.But 5 years surivival rates,the recurrence rates and infection rates postopretion of patients were statistical different. Conclusion 5 Fu keep down clysis pre opretion and 5 Fu/CF iv. postopretion can increase 5 years surivival rates and decrease recurrence rates of patients were with rectal cancer.
出处
《临床外科杂志》
2001年第4期207-208,共2页
Journal of Clinical Surgery
关键词
灌肠化疗
辅助化疗
直肠癌
治疗
Rectal neoplasms
Clysis chemotherapy
Adjuvant chemotherapy
