摘要
报告81例各种恶性肿瘤病人，共接受导管化疗144例次。均采用Seldinger技术插管，行相应动脉内灌注化疗（108例次）或油剂化学栓塞（36例次）。结果：64例治疗后WBC下降，统计学处理显示对WBC下降有意义的危险因素包括年龄大于50岁、曾接受过放疗或化疗、肝功能不全、同时联用ADM及MMC，MMC用量每次大于10mg。本文首次提出药物全部灌注而不施行油剂化学栓塞是WBC下降的重要危险因素。故尽可能施行油剂化学栓塞，改变药物剂量分布，减少全身血药浓度．是防止导管化疗后WBC下降的有效方法。应充分注意导管化疗方案的个体化。
Eighty-one cases of malignant tumors received transcatheter arterial chemotherapy or oil-chemo-embolization using Seldinger technique. Leukopeniaoccurred in 64 patients after treatment. It was found that the risk factors of de-escalation of WBC included age older than 50 years, a past history of chemotherapy orradiotherapy, impairment of liver function, ADM and MMC simultaneously andover-dosage of MMC. It is this paper that reports for the first tirne that all the anticancer agents administered by infusion without oil-chemo-embolization is the mainrisk factor inducing leukopenia.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1997年第10期742-744,共3页
Chinese Journal of Clinical Oncology
关键词
介入治疗
血白细胞
肿瘤
药物疗法
Interventional treatment Chemotherapy Leukopenia
