摘要
卡维地洛 (Carvedilol)是新一代具有扩张血管和强有力的抗氧化作用的非选择性 β受体阻滞剂 ,它在抗氧化作用、减少心肌细胞凋亡、改善左心功能和降低心力衰竭患者病死率方面 。
Carvedilol is a novel β receptor blocker with vasodilative and potent antioxidative effects. It may inhibit the activation of transduction factors induced by oxygen radicals, block the gene expression in cardiac remodeling, and decrease cardiomyocyte apoptosis. It is reported that carvedilol may reduce the in vivo oxidation of low density lipoprotein (LDL) and auto antibody titre of antioxidant and increase the antioxidative capacity of LDL. Carvedilol and its metabolite BM 910228 may inhibit the inotropic response induced by oxygen radicals. Carvedilol may provide cardiac protection in acute myocardial ischemia and improve cardiac function, reduce the mortality rate of heart failure.
出处
《医学研究生学报》
CAS
2001年第3期265-267,共3页
Journal of Medical Postgraduates
