期刊文献+

卡维地洛治疗慢性心力衰竭的疗效分析 被引量:7

Analysis of Curative Effect to Carvedilol on Chronic Cardiac Failure
暂未订购
导出
摘要 目的探讨卡维地洛治疗慢性心力衰竭的临床疗效。方法选择84例慢性心力衰竭患者,随机分为治疗组和对照组,各42例,均给予强心、利尿、扩血管等治疗基础治疗,治疗组患者另外给予卡维地洛治疗,小剂量起始,逐渐增加至靶剂量,比较两组患者临床治疗效果。结果治疗组有效率92.8%,对照组有效率83.3%,治疗组有效率高于对照组,治疗组患者心率(HR)、收缩压(SBP)、舒张压(DBP)、左室舒张末径(LVEDD)低于对照组,左室射血分数(LVEF)高于对照组。结论卡维地洛能够改善慢性心力衰竭患者左心功能,增强治疗效果。 Objective To investigate the cinical curative effect of carvedilol on chronic cardiac failure.Methods 84 cases of patients with chronic cardiac failure were selected and divided into therapia groups(n=42) and control groups(n=42),all patients taken treatment with cardiotonic,diuretic and expanding durgs,patients received treatment with carvedilol from small dose to target dosage.cinical curative effect were contrasted between therapia groups and control groups.Results Clinical effective power was 92.8% in therapia groups and was 83.3% in control,clinical effective power was higher in therapia groups than in control groups,level of HR,SBP and LVEDD was lower,level of LVEF was higher in therapia groups than in control groups.Conclusion Carvedilol could improve left heart function on patients with chronic cardiac failure and improve curative effect.
出处 《实用心脑肺血管病杂志》 2012年第2期197-198,共2页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词 卡维地洛 心力衰竭 心脏功能试验 治疗结果 Carvedilol Heart failure Heart function tests Treatment outcome
  • 相关文献

参考文献9

二级参考文献59

  • 1李勇,诸骏仁.β受体阻滞剂治疗慢性心力衰竭——COMET研究的意义[J].中华心血管病杂志,2004,32(5):466-468. 被引量:50
  • 2张莉.卡维地洛治疗充血性心力衰竭疗效观察[J].中国药业,2007,16(9):56-56. 被引量:3
  • 3[11]Santos DJ, Moreno AJ. Inhibition of heart mitochondrial lipid peroxidation by non-toxic concentrations of carvedilol and its analog BM-910228 [J]. Biochem Pharmacol ,2001,61 (2): 155-164.
  • 4[12]Noguchi N, Nishino K,Niki E. Antioxidant action of the antihypertensive drug,carvedilol, against lipid peroxidation [J]. Biochem Pharmacol, 2000, 59 ( 9 ):1069-1076.
  • 5[13]Rossig L, Haendeler J, Mallat Z, et al. Congestive heart failure induces endothelial cell apoptosis :protective role of carvedilol [J]. J Am Coll Cardilo,2001 ,36( 7 ) :2081-2089.
  • 6[14]Romeo F,LiM D,Shi M ,et al. Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells:modulation of Fas/Fsa ligand and caspase-3 pathway [ J ]. Cardiovasc Res, 2000,45 ( 3 ) :788-794.
  • 7[15]Cao F,Chen J,Lopez BL,et al. Comparison of bisoprolol and carvedilol cardioprotection in a rabbit ischemia and reperfusion model [ J ]. Eur J Pharmacol,2000,406( 1 ) :109-116.
  • 8[16]Wei S.Chow LT,Sanderson JE,et al. Effect of carvedilol in comparison with metoprolol on myocardial collagen postinfarction[J]. J Am Coll Cardiol.2000,36( 1 ) :276-281.
  • 9[17]Ohta Y, Watanabe K, Nakazawa M,et al. Carvedilol enhances atrial and brain natriuretic peptide mRNA expression and release in rat heart[ J ]. J Cardiovasc Pharmacol,2000,36 ( suppl 2 ) 19-23.
  • 10[18]Savitz SI, Erhardt JA, Anhtony JV, et al. The novel β-bolcker, carvedilol, provides neuroprotection in transient focal stroke[J]. J Cereb Blood Flow Metab,2000,20(8) :1197-1204.

共引文献61

同被引文献88

引证文献7

二级引证文献52

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部