摘要
目的 :运用磁共振灌注成像(PWI)获取对比剂首过期间的兴趣区图像 ,评价rCBV和rCBF在术前评估脑胶质瘤组织学分级中的价值。材料和方法 :本组共30例颅脑胶质瘤 ,均经病理证实。常规MRI扫描后行PWI ,PWI序列为GRE -EPIT2 * WI ,由灌注资料获取rCBV、rCBF图像 ,计算最大rCBV和rCBF并与组织病理学分级对照。结果 :Ⅲ～Ⅳ级胶质瘤(18例)的rCBF、rCBV分别为1.8～7.4和2.67～10.48 ,均值分别为5.4±1.8和5.75±3.85。Ⅰ～Ⅱ级胶质瘤(12例)rCBF、rCBV分别为0.5～1.7和1.36～3.16 ,均值分别为1.4±0.3和1.75±0.65。两组间rCBF和rCBV差别有显著性(p<0.01 ,studentt检验)。结论 :灌注成像对颅脑胶质瘤的术前分级有重要价值。
Purpose:To evaluate the potential of rCBV and rCBF in preoperative assessment of tumor grade of glioma by means of perfusion MR imaging.Materials and methods:Perfusion MR imaging was performed preoperatively in 30 patients with pathologically proven cerebral gliomas by using first pass Gd-DTPA T2*-weighted echo-planar sequence followed by conventional imaging.The perfusion data were deconvoluted to get a color map of rCBV and rCBF.The maximal rCBV and rCBF of each lesion was correlated with histopathologic grading of gliomas.Results:The rCBF and rCBV in grade Ⅲ～Ⅳ gliomas(n=18) were 1.8～7.4 and 2.67～10.48 respectively,with a mean of 5.4±1.8 and 5.75±3.85.The rCBF and rCBV in grade Ⅰ～Ⅱ gliomas(n=12) varied from 0.5～1.7 and 1.36～3.16 with a mean 1.4±0.3 and 1.75±0.65.The difference in rCBF and rCBV was statistically significant between grade Ⅲ～Ⅳ and Ⅰ～Ⅱ gliomas(student t test).Conclusion:Perfusion MR imaging is very usful in preoperative predicting tumor grade of gliomas.
出处
《中国医学计算机成像杂志》
CSCD
2001年第3期157-159,共3页
Chinese Computed Medical Imaging
基金
安徽省自然科学基金资助(No.99044530)
关键词
胶质瘤
磁共振成像
灌注
病理
Glioma Magnetic resonance imaging Perfusion
