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磁共振灌注成像对局部进展期乳腺癌新辅助化疗疗效的评价 被引量:18

Using perfusion MRI in the evaluation of response of locally advanced breast cancer to neoadjuvant chemotherapy
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摘要 目的:探讨磁共振T2*WI首次通过灌注成像对局部进展期乳腺癌新辅助化疗疗效评价及其作为化疗反应预测因子的可行性。方法:根据新辅助化疗后体积改变将10例乳腺癌分为反应组和无反应组,比较分析化疗前后肿瘤体积、最大信号丢失率变化及化疗前最大信号丢失率与肿瘤缩退率间的相关关系。结果:化疗前两组体积及最大信号丢失率差异均无统计学意义(P>0.05);反应组化疗后最大信号丢失率显著降低(P<0.05);1个疗程后肿瘤最大信号丢失率的下降具有统计学差异(P<0.05),而体积改变无统计学差异(P>0.05);化疗前最大信号丢失率与肿瘤缩退率间具有正相关关系,但无统计学意义(r=0.313,P>0.05)。结论:T2*WI首次通过灌注成像可早期评价乳腺癌新辅助化疗疗效,但其作为化疗反应的预测因子有待于进一步研究。 Objective:Using T2* weighted first-pass MR perfusion imaging to evaluate neoadjuvant chemotherapy in patients with locally advanced breast cancer,and its feasibility as a predicting factor for the response to neoadjuvant chemotherapy.Methods:Ten patients were divided into response group and non-response group according to the changes of tumor size after neoadjuvant chemotherapy.Changes of the tumor volume and the maximal signal intensity decrease ratio of PWI between the two groups before and after chemothe...
出处 《放射学实践》 北大核心 2011年第1期25-29,共5页 Radiologic Practice
基金 上海市科学技术委员会科研计划项目(09411962800)
关键词 乳腺肿瘤 抗肿瘤联合化疗方案 磁共振成像 Breast neoplasms Antineoplastic combined chemotherapy protocols Megnetic resonance imaging
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参考文献15

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