摘要
目的 观察胎儿宫内生长迟缓 (IUGR)患者的胎盘免疫病理学改变 ,并探讨IUGR的发病机理。方法 采用免疫组织化学技术 ,对 2 2例不明原因IUGR(不明原因IUGR组 )、10例妊娠高血压综合征 (妊高征 )合并IUGR(妊高征合并IUGR组 )、2 3例正常产妇 (正常妊娠组 )的胎盘免疫病理学改变进行观察。结果 (1) 3组胎盘绒毛内血管IgG的阳性例数分别为 :不明原因IUGR组 19例 ,妊高征合并IUGR组 10例 ,正常妊娠组 17例 ,3组比较 ,差异无显著性 (P >0 0 5 )。(2 )不明原因IUGR组与妊高征合并IUGR组的绒毛内血管IgM阳性例数分别为 8例及 4例 ,而正常妊娠组则无一例阳性。(3)不明原因IUGR组与妊高征合并IUGR组的胎盘蜕膜血管IgG、IgM阳性例数 ,以及滋养细胞IgM染色强度均高于正常妊娠组。而不明原因IUGR组与妊高征合并IUGR组之间比较 ,差异无显著性 (P>0 0 5 )。(4 )不明原因IUGR组中 ,抗心磷脂抗体 (ACA)阳性与阴性患者的胎盘免疫复合物沉积状况比较 ,差异无显著性 (P >0 0 5 )。结论 胎盘免疫复合物沉积在IUGR的发病中起重要作用。不明原因IUGR与妊高征合并IUGR具有相似的胎盘免疫病理改变。ACA导致IUGR的机理是否与胎盘免疫复合物的沉积有关 。
Objective To observe the immune complex distribution in placenta of intrauterine growth retardation (IUGR). Method Using immunohistochemical technique (SP method), authors studied the deposition of IgG and IgM in the placenta of idiopathic IUGR patients (including 8 samples of (ACA) positive and 14 samples of ACA negative) and patients with Pregnancy induced hypertension (PIH) complicated IUGR. Results There is no significant difference of IgG deposition in villous vessels among the three groups. The positive rate of IgM in villous vessels、the positive rate of IgG、IgM in decidual vessels and the deposition of IgM in syncytiotrophoblast of both idiopathic IUGR and PIH complicated IUGR were much higher than those of control group ( P >0.05). The positive rates of IgG、IgM in decidual vessels and villous vessels between the ACA positive group and ACA negative group in the idiopathic IUGR were not significantly different. Conclusions The immunopathological lesion in placenta might play an important role in the development of IUGR. Idiopathic IUGR and PIH complicated IUGR have the similar placental immunopathological changes. The etiology of IUGR induced by ACA needs more studies.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2001年第4期202-205,共4页
Chinese Journal of Obstetrics and Gynecology
基金
广东省自然科学基金资助 (A0 0 2 0 0 0 0 0 3 )
关键词
胎儿生长迟缓
胎盘
免疫组织化学
病理学
Fetal growth retardation
Placenta
Immunohistochemistry
Pathology
