摘要
目的:研究血管内皮生长因子(VEGF)在脑膜瘤中的表达及其与脑膜瘤增殖活性、微血管密度及瘤周脑水肿(PTBE)的关系。方法:应用免疫组化方法检测36例脑膜瘤组织中VEGF、增殖细胞核抗原(PCNA)、第Ⅷ因子(F8)的表达,测定其阳性细胞数;PTBE 通过术前颅脑 MHI/CT来评估。结果:脑膜瘤 VEGF表达率为 72％(26/36)5例可疑表达 ; PCNA、F8全部表达。VEGF 表达与PTBE 和微血管密度有显著正相关关系,其r分别为 0.878和0.631 ;VECF 表达与 PCNA表达没有相关性,其r为0.087。PCNA 标记指数<25％占97％(35/36)。结论:VEGF 存在于脑膜瘤组织中,在PTBE 和微血管形成方面起着重要的作用。脑膜瘤属于低增殖活性的良性肿瘤。
Objective: To study the expression of vascular endothelial growth factor(VEGF)in menin-giomas correlated with proliferating cell nuclear antigen(PCNA)、Factor 8 and peritumoral brain edema(PTBE). Methods: The expression of VEGF, PCNA, Factor 8 in 36 cases of meningiomas was detected byimmunohistochemical. PTBE was assessed using preoperative MRI or CT scan. Results: The expression ofVEGF was found in 72% (26/36), PCNA and Factor 8 were expressed in all cases.The expression ofVEGF had positive correlation with PTBE and microvascular density, the expression of VEGF had notcorrelation with PCNA,PCNA labeling index were below to 25% in 97% (35/36). Conclusion: VEGFpresence and contributes to PTBE formation and angiogenesis in meningiomas. Meningiomas belong to be-nign tumor with low proliferating potential.
关键词
脑膜瘤
血管内皮生长因子
增殖细胞核抗原
脑水肿
Meningiomas
Vascular endothelial growth factor
Proliferating cell nuclear antigen
Brain edema
