摘要
目的 探讨三阴性乳腺癌的临床病理特征及TopoⅡα、Ki67表达情况.方法 分析78例三阴性乳腺癌患者发病年龄、肿瘤大小、组织学类型、淋巴结转移情况;同时采用免疫组化EnVision二步法检测TopoⅡα、Ki67蛋白表达水平,并与同期1 14例非三阴性乳腺癌患者比较.结果 三阴性乳腺癌组患者腋窝淋巴结转移率高于非三阴性乳腺癌患者,两组比较差异有统计学意义（P＜0.05）;随着肿瘤的增大,三阴性乳腺癌患者腋窝淋巴结转移率明显增高,两者呈正相关（P＜ 0.05）;Non-TNBC组Ki67阳性率低于TNBC组,差异有统计学意义（x2=4.003,P=0.045）.结论 三阴性乳腺癌侵袭性强、淋巴结转移率高,具有更高的肿瘤增殖活性,预后较其他类型患者差.
Objective To investigate the clinicopathological characteristics and the expression of Topo Ⅱ α,Ki67 in triple negative breast cancer （TNBC）.Methods The clinicopathological characteristics in TNBC group were analyzed,including year,tumor size,lymph node metastasis and histological type; the expression of Topo Ⅱ α and Ki67 was determined by immunohistochemical techniques （EnVision）.And we compared the differences between TNBC group （78 cases） and the non-triple negative breast cancer （nonTNBC） group （114 cases）.Results The positive rate of axillary lymph node metastasis in TNBC group was higher than that in non-TNBC group,which difference was significant （P ＜ 0.05） ; With the increase of the tumor size,the positive rate of axillary lymph node metastasis in TNBC group was significantly higher,The positive rate of axillary lymph node metastasis was correlated positively with the tumor size （P ＜ 0.05） ;the expression of Ki67 in non-TNBC group was significantly lower than that in TNBC group （x 2=4.003,P=0.045）.Conclusion Compared with non-TNBC group patients,TNBC group patients have a higher risk of local invasion,lymph node metastasis,cell proliferation and poorer survival.
出处
《国际医药卫生导报》
2014年第3期325-328,共4页
International Medicine and Health Guidance News
